Recent research reveals that the liver, in addition to the brain, has an impact on the body’s internal circadian clock. A team of scientists from the University of Queensland’s Institute for Molecular Bioscience in Australia and Université Paris Cité/CNRS in France discovered that by replacing mice’s liver cells with human cells, the circadian rhythm of mice can be altered. The implanted human cells caused mice to become active and eat at different times than mice without the transplanted cells. The usual nocturnal patterns of mice shifted as the implanted cells advanced their circadian clock by two hours. The study suggests that restoring liver function could promote overall health and well-being, particularly for patients with liver or metabolic diseases, such as diabetes and obesity. The circadian clock regulates various physiological processes, such as sleep-wake cycles, hormone production, and body temperature. Disruptions in the circadian clock, as seen in circadian rhythm sleep disorders, have effects on health conditions. The research is published in Science Advances.