The federal government of Canada has announced stricter regulations on chemicals used in the production of fentanyl beginning on August 30. The aim is to address the devastating impact of the overdose crisis and the toxic illegal drug supply in the country. Health Canada stated that nearly 75 percent of accidental opioid deaths and overdoses since 2017 have involved fentanyl or related substances. The regulatory changes will categorize a specific group of chemicals, known as novel fentanyl precursors, as controlled substances under the Controlled Drugs and Substances Act (CDSA). These chemicals, which are analogues and derivatives of N-phenyl-4-piperidinamine and its salts (also called 4-AP), have no legitimate industrial, commercial, or medical purposes, and controlling their use will help combat the illegal production of fentanyl and its analogues. Health Canada also emphasized that this measure will enable law enforcement to take action against the illegal importation, distribution, and use of these precursor chemicals. These regulatory changes follow a temporary ministerial order implemented for one year to disrupt the illegal importation and distribution of precursor fentanyl chemicals. Minister of Public Safety Marco Mendicino stressed the importance of taking action at the border to prevent the entry of illegal drugs like fentanyl precursors into Canada. The U.S. Drug Enforcement Agency has implemented similar regulations under the Controlled Substances Act in the United States. The data on opioid and stimulant harms in Canada has revealed an alarming trend, with opioid-related deaths more than doubling since 2016. In 2021, the country experienced an all-time high of 21 opioid-related deaths per day. The number of opioid-related hospitalizations has also increased from 13 per day in 2016 to 17 per day in 2021. To address this crisis, the Canadian government has invested over $1 billion in efforts to improve access to harm reduction services and treatment, fund awareness and prevention activities, support research and surveillance initiatives, and strengthen law enforcement capabilities in tackling illegal drug production and trafficking. The government has also provided border services officers with the necessary tools and equipment to detect and interdict fentanyl and other toxic substances at the border. Since April 2018, the Canada Border Services Agency (CBSA) has seized over 20 kilograms of fentanyl and more than 22,000 kilograms of other narcotics, drugs, and chemicals. The CBSA has chemists and drug and gun detector dog teams located in Toronto, Montreal, and Vancouver.